2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
    Neuronal Signaling
  4. TRP Channel

TRP Channel

Transient receptor potential channels

TRP Channel

Related Products

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TRP Channel (Transient receptor potential channel) is a group of ion channels located mostly on the plasma membrane of numerous human and animal cell types. There are about 28 TRP channels that share some structural similarity to each other. These are grouped into two broad groups: Group 1 includes TRPC ("C" for canonical), TRPV ("V" for vanilloid), TRPM ("M" for melastatin), TRPN, and TRPA. In group 2, there are TRPP ("P" for polycystic) and TRPML ("ML" for mucolipin). Many of these channels mediate a variety of sensations like the sensations of pain, hotness, warmth or coldness, different kinds of tastes, pressure, and vision. TRP channels are relatively non-selectively permeable to cations, including sodium, calcium and magnesium. TRP channels are initially discovered in trp-mutant strain of the fruit fly Drosophila. Later, TRP channels are found in vertebrates where they are ubiquitously expressed in many cell types and tissues. TRP channels are important for human health as mutations in at least four TRP channels underlie disease.

TRP Channel Isoform Specific Products:

TRP Channel Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-121080
    AMG8163
    		Antagonist
    AMG8163 is an orally active antagonist for TRPV1. AMG8163 inhibits Capsaicin (HY-10448)-induced flinch in rats models, and exhibits anti-hyperalgesia effects in multiple pain models.
    AMG8163
  • HY-W721480
    HC-067047 hydrochloride
    		Antagonist
    HC-067047 hydrochloride is a potent and selective TRPV4 antagonist and reversibly inhibits currents through the human, rat, and mouse TRPV4 orthologs with IC50 values of 48 nM, 133 nM, and 17 nM, respectively.
    HC-067047 hydrochloride
  • HY-110270A
    RN-9893 hydrochloride
    		Antagonist
    RN-9893 Hydrochloride is an orally active antagonist of transient receptor potential vanilloid 4 (TRPV4), with IC50 values of 0.42 and 0.66 μM, for humans and rats, respectively.
    RN-9893 hydrochloride
  • HY-172106
    TRPC5-IN-5
    		Inhibitor
    TRPC5-IN-5 (Compound ph8) is a TRPC5 inhibitor (IC50: 1.28 μM). TRPC5-IN-5 can be used for research of neurological diseases and renal diseases.
    TRPC5-IN-5
  • HY-10448AR
    Capsaicin (Purity 65%) (Standard)
    		Agonist
    Capsaicin (Purity 65%) (Standard) is the analytical standard of Capsaicin (Purity 65%). This product is intended for research and analytical applications. Capsaicin (Purity 65%) is a mixture of Capsaicin and Dihydrocapsaicin (Ratio >2:1).Capsaicin (Purity 65%) is an orally active capsaicin receptor (TRPV1) agonist.
    Capsaicin (Purity 65%) (Standard)
  • HY-161766
    L687
    		Activator
    L687 is a potent activator of TRPC3/C6/C7 that can induce cellular uptake of oligonucleotides.
    L687
  • HY-128561
    AM12
    		Activator
    AM12 inhibits Lanthanide-evoked TRPC5 activity with an IC50 of 0.28 μM.
    AM12
  • HY-118535
    N-Oleoyl valine
    		Antagonist
    N-Oleoyl valine is a N-acyl valine compound that acts as a TRPV3 receptor antagonist.
    N-Oleoyl valine
  • HY-146155
    TRPC4/5-IN-1
    		Inhibitor
    TRPC4/5-IN-1 is a potent TRP channel 4/5 (TRPC4/5) inhibitor with IC50s of 2.06 μM and 0.54 μM, respectively. TRPC4/5-IN-1 can be used for proteinuric kidney diseases and skin inflammatory diseases research.
    TRPC4/5-IN-1
  • HY-N2941
    Bisandrographolide C
    		Activator
    Bisandrographolide C is an unusual dimer of ent-labdane diterpenoid isolated and identified from Andrographis paniculata. Bisandrographolide C activates TRPV1 and TRPV3 channels with Kd values of 289 and 341 μM respectively, and protects cardiomyocytes from hypoxia-reoxygenation injury.
    Bisandrographolide C
  • HY-B0151S
    Pregnenolone-d4
    		Activator
    Pregnenolone-d4 is the deuterium labeled Pregnenolone. Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid, the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication[1][2]. Pregnenolone is also a TRPM3 channel activator, and also can weakly activate TRPM1 channels[3].
    Pregnenolone-d<sub>4</sub>
  • HY-118299
    JYL 1511
    		Agonist
    JYL 1511 is a partial agonist of vanilloid receptor VR1.
    JYL 1511
  • HY-10448S4
    Capsaicin-d7
    		Agonist
    Capsaicin-d7 is deuterated labeled Capsaicin (HY-10448). Capsaicin ((E)-Capsaicin), an active component of chili peppers, is a TRPV1 agonist. Capsaicin has pain relief, antioxidant, anti-inflammatory, neuroprotection and anti-cancer effects.
    Capsaicin-d<sub>7</sub>
  • HY-162584
    TRPC4/5-IN-2
    		Inhibitor
    TRPC4/5-IN-2 (Compound 12) is an orally effective transient receptor potential (TRPC5) inhibitor with a IC50 value of 81 nM. TRPC4/5-IN-2 has good biosafety and low liver and kidney toxicity, and is expected to play an important role in the treatment of chronic kidney disease (CKD).
    TRPC4/5-IN-2
  • HY-142030
    TRPC5 modulator-1
    		Modulator
    TRPC5 modulator-1 (Compound 9) is a TRPC5 modulator with an IC50 of <1 nM for the research of neuropsychiatry disorders.
    TRPC5 modulator-1
  • HY-135881
    OMDM-5
    		Agonist
    OMDM-5 is a selective inhibitor of anandamide cellular uptake (ACU), with a Ki of 4.8 μM. OMDM-5 is also a potent vanilloid receptor type 1 (VR1, TRPV1) agonist, with an EC50 of 75 nM, and shows weakly active as cannabinoid receptor type 1 (CB1) ligand (Ki=4.9 μM).
    OMDM-5
  • HY-109841S
    Oleoyl Serotonin-d17
    Oleoyl Serotonin-d17 is the deuterium labeled Oleoyl Serotonin[1].
    Oleoyl Serotonin-d<sub>17</sub>
  • HY-120818
    TRPC3/6-IN-3
    TRPC3/6-IN-3 is a selective TRPC3/6 blocker. TRPC3/6-IN-3 can be used for the research of cardiovascular disease.
    TRPC3/6-IN-3
  • HY-P1175
    L-R4W2
    		Antagonist
    L-R4W2 is a potent antagonist of vanilloid receptor 1 (VR1, TRPV1), with an IC50 of 0.1 μM. L-R4W2 may act as a potent analgesic.
    L-R4W2
  • HY-142620
    TRPV4 antagonist 3
    		Antagonist
    TRPV4 antagonist 3 is a TRPV4 antagonist (pIC50 = 8.4).
    TRPV4 antagonist 3
Cat. No. Product Name / Synonyms Application Reactivity
TRP Channel Isoform Comparison

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